Korean J Bone Metab > Volume 12(1); 2005 > Article
Korean Journal of Bone Metabolism 2005;12(1):1-7.
The Association between Oxidative Stress in Bone Marrow with Bone Metabolism
골수내 산화 스트레스가 골대사에 미치는 영향
가톨릭대학교 의과대학 내과학교실, 신경외과학교실2 및 임상의학 연구소1, 성균관대학교 의과대학 강북삼성병원 내과3, 한림대학교 의과대학 평촌성심병원 내과4
Backgroud: Osteoporosis is associated with many etiological causes such as nutrition, cytokines, hormones and aging. Reactive oxygen species (ROS) have recently been shown to be responsible for the aging process and osteoporosis. ROS that is produced either endogenously or exogenously can simultaneously attack lipid, protein and nucleic acid in the living cells.
In this study, we studied the effect of oxidative stress on bone metabolism in 24 men and 15 women by determining the levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in bone marrow samples and then examining their association with BMD and bone turnover markers measured from the same specimen.
In the age-, sex-, weight- and smoke status- adjusted model, the bone marrow 8-OHdG levels showed positive correlation with the level of bone marrow ICTP as a bone resorption marker (γ=0.36, p<0.05). Although statistically not significant, the 8-OHdG levels tended to be positively associated with the level of BSAP as a bone formation marker and there was a trend for negative correlation between the 8-OHdG level and bone mineral density at the lumbar spine and femoral neck.
Taken together, these results suggest that increased oxidative stress in bone marrow could be involved in negative balance in the bone metabolism. This was demonstrated for the first time by our analysis of the relationship between bone metabolism and oxidative stress in bone marrow serum, and these results provide a rational for further studies about the role of antioxidants in osteoporosis.
Key Words: Oxidative stress, 8-OHdG, Bone mineral density, Osteoporosis


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