Korean J Bone Metab > Volume 18(1); 2011 > Article
Korean Journal of Bone Metabolism 2011;18(1):49-54.
Could Prior Oral-bisphosphonate Administration Reduce the Acute Phase Reaction of Zoledronate?
경구용 비스포스포네이트의 사전 투여는 졸레드로네이트의 급성이상반응을 줄일 수 있는가?
서성화1,조환성2,천상호2,정혜미3,박일형2*
경북대학교 대학원 의과학과1, 경북대학교 의학전문대학원 정형외과학교실2, 경북대학교 대학원 통계학과3
Abstract
Objective
Bisphosphonates are the most commonly prescribed medications for the treatment of osteoporosis. This study was designed to analyze the rate of acute phase reaction (APR) following Zoledronate 5 mg administration in patients with osteoporosis who were treated with prior oral bisphosphonate for at least 2 weeks and to compare naïve IV 5 mg Zoledronate.
Methods
Between July 2009 and October 2010, 27 patients with osteoporosis who were treated with prior oral bisphosphonate for at least 2 weeks, and maximum 52 weeks (average 18.5 weeks) and were between 42-and 85-year-old at the time of study participation. We prospectively evaluated APR, including fever, flu-like symptoms, headache, arthralgia, and myalgia, after 5 mg zoledronate by questionnaire. Additionally we assessed a visual analogue scale (VAS) by 4-point categorical scale.
Results
In this study of 27 patients with osteoporosis, the frequency of APR, flu-like symptom and myalgia were 14.8% and 7.4% and fever, arthralgia, and headache were 3.7% respectively. In VAS, all reactions were mild. The rate of APR rate in this study was statistically decreased compared to previous reports with zoledronate 5 mg IV in bisphosphonate-naïve patients.
Conclusion
Prior oral bisphosphonate administration for at least 2 weeks could significantly reduce the APR of IV zoledronate 5 mg.
Key Words: Acute phase reaction, Oral bisphosphonate, Zoledronic acid
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