Korean J Bone Metab > Volume 17(2); 2010 > Article
Korean Journal of Bone Metabolism 2010;17(2):103-107.
Predictors of Acute Phase Response after Intravenous Zoledronic Acid in Patients with Osteoporotic Fracture
Young-Kyun Lee1 Ji Hoon Baek Yong-Chan Ha* Kyung-Hoi Koo1
Department of Orthopaedic Surgery, College of Medicine, Chung-Ang University, Seoul, South Korea Department of Orthopaedic Surgery1, College of Medicine, Seoul National University Bundang Hospital, South Korea
Abstract
Objective
Acute phase response (APR) is the most common adverse event of the intravenous zoledronic acid, and can reduce the compliance of annual injection. The purpose of this study is to determine the predictor of APR after 5 mg zoledronate in patients with osteoporotic fractures.
Methods
In this prospective study, patients admitted with osteoporotic fracture, > 50 years of age, and who were willing to receive zoledronic acid during hospital stay were eligible. During hospital stay, we prospectively evaluated APR, including fever, flu-like symptoms, headache, arthralgia, and myalgia, after 5 mg zoledronate. We evaluated the predictors in demographic data by multivariate analysis.
Results
In this study of 159 patients with osteoporotic fractures, the frequency of APR, fever was 32.1%, and 22.0%. The significant predictor of APR were higher bone mass index (BMI) and male gender in multivariate analysis, especially in terms of fever.
Conclusion
This study showed that predictors of APR after intravenous zoledronic acid are male gender and higher BMI. Although those were uncorrectable factors before intravenous administration, these concerns on the APR such as fever can reassure the predictive patients, and minimize compliance decreases. [Korean Journal of Bone Metabolism, 17(2): 103-107, 2010]
Key Words: Acute phase response, Predictor, Zoledronic acid
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