Korean J Bone Metab > Volume 16(2); 2009 > Article
Korean Journal of Bone Metabolism 2009;16(2):95-105.
Serum Vitamin D and Parathyroid Hormone Levels in Patients with Osteoporotic Hip Fracture
골다공증성 고관절 골절 환자에서 비타민 D와 부갑상선 호르몬의 혈청 농도
차영찬,김지완,정미혜,이진용1,장재석
울산대학교 의과대학 서울아산병원 정형외과학교실, 노스캐롤라이나 주립대학교 보건대학원1
Abstract
Objective
The purpose of this study was to examine relationship between serum vitamin D and parathyroid hormone (PTH) levels in patients with osteoporotic hip fracture. In addition, bone mineral density (BMD), body mass index (BMI), albumin, osteocalcin, and calcium intake were measured and analysis was performed.
Methods
There were 193 patients who had hip fracture by mild trauma from 2005 to 2009. Some patients who had preexisting conditions affecting vitamin D synthesis and bone metabolism were excluded. Finally, 119 patients were chosen as study subjects. Patients' serum vitamin D, PTH, albumin, osteocalcin, calcium intake, BMD, BMI were examined and compared with another. Also compared with control group.
Results
The mean levels of serum vitamin D, PTH, and osteocalcin were 21.6 ng/mL, 33.6 pg/mL, 19.0 ng/mL in patients and were 33.9 ng/mL, 31.6 pg/mL, 25.4 ng/mL in control. Also, average of BMI, albumin, calcium intake were 22.6, 3.3 g/L, 484.4 mg/day in patients. There was 82.4% of patients decreased vitamin D below 30 ng/mL and 21.0% of patients decreased below 10 ng/mL. Only 9.8% of patients with vitamin D below 30 ng/mL were above 65 pg/mL in PTH.
Conclusion
There was 82.4% of hypovitaminosis D in patients with osteoporotic hip fracture. However, parathyroid hormone did not increase significantly. We conclude that serum vitamin D reduction may be one of risk factors in osteoporotic hip fracture. [Korean Journal of Bone Metabolism, 16(2): 95-102, 2009]
Key Words: Hip fracture, Osteoporosis, Parathyroid hormone, Vitamin D


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