Korean J Bone Metab > Volume 16(2); 2009 > Article
Korean Journal of Bone Metabolism 2009;16(2):79-85.
Bone Mineral Density Changes During Androgen Deprivation Therapy for Patients with Prostate Cancer
남성호르몬차단요법을 시행한 전립선암 환자에서의 골밀도 변화
이승준,이동길,박정현,김재한,송강현,박종욱,길명철,조문기
원자력병원 비뇨기과
Abstract
Purpose
Androgen deprivation therapy (ADT) improves survival of patients with prostate cancer but leads to hypogonadal state. Gonadal hormones are essential for bone integrity and hypogonadism from ADT constitutes a major risk factor for osteoporosis. We investigated bone mineral density (BMD) changes according to duration of ADT and other clinical factors.
Methods
A total of 102 patients with prostate cancer receiving ADT and 37 men of controls were evaluated. Dual energy x-ray absorptiometry was used to assess BMD at the lumbar spine. Age, body mass index (BMI), BMD, Gleason score, initial prostate-specific antigen (PSA), duration of ADT, smoking history, history of diabetes mellitus (DM), hypertension and preventive therapy of osteoporosis were obtained and analyzed.
Results
BMD of prostate cancer patients with ADT was significantly lower than that of controls. Old age and low BMI were correlated with low BMD. Longer duration of ADT made more decrease in BMD of prostate cancer patients receiving ADT. Preventive therapy of osteoporosis during ADT showed significant correlation with high BMD and also decreased bone mass loss rate per year.
Conclusions
Our study indicated that BMD was associated with ADT and its duration. Anti-osteoporotic therapy could decrease bone mass loss. Therefore we suggest that clinicians should be aware of impact of ADT on BMD to prevent osteoporosis. [Korean Journal of Bone Metabolism, 16(2): 79-85, 2009]
Key Words: Bone density, Osteoporosis, Prostatic neoplasms, Androgens
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