| Novel Association between Bone Mineral Density and Leptin Receptor Gene
Polymorphism in Young Men
|
| 젊은 남성에서 골밀도와 렙틴 수용체 유전자
다형성과의 상관관계
|
| 고정민,김덕재,홍정수2,김재승1,김신윤3,김기수 |
| 울산대학교 의과대학 서울중앙병원 내과학교실, 핵의학과학교실1,
아산생명과학연구소2, 경북대학교 의과대학 정형외과학교실3
|
|
|
| Abstract |
|
Previous studies have suggested that leptin regulates bone metabolism. We investigated associations between bone mineral density (BMD) and polymorphisms of the leptin receptor (LEPR) gene in young men.
From 157 healthy volunteers aged 20~34 years, we genotyped the Lys109Arg, Gln223Arg, Ser492Thr, Ala976Asp, and Pro1019Pro variants of LEPR using the polymerase chain reaction-restriction fragment length polymorphism method. We determined serum leptin concentration by radioimmuno assay (RIA) and BMD by dual energy X-ray absorptiometry.
The subjects carrying the Gln223 allele of LEPR had higher BMD at the lumbar spine compared with the subjects without this allele and the association was more pronounced in the overweight at both the lumbar spine and proximal femur. There was no significant differences in age, body weight and serum leptin concentrations between the two groups. However, Lys109Arg and Pro1019Pro polymorphisms of LEPR were not associated with BMD at all sites, and polymorphisms of Ser492Thr and Ala976Asp could not be analyzed for possible associations with BMD because their polymorphisms were rare.
This study indicates that the Gln223Arg polymorphism of LEPR is important for determination of the peak bone mass in young men and this association becomes more pronounced in overweight subjects.
|
| Key Words:
Bone density, Men, Leptin receptors, Polymorphism |
|
PDF Links
Full text via DOI
Download Citation
