Korean J Bone Metab > Volume 9(2); 2002 > Article
Korean Journal of Bone Metabolism 2002;9(2):163-169.
Effect of Treatment with HRT and HMG-CoA Reductase Inhibitor on BMD in Postmenopausal Korean Women
여성호르몬과 병합 사용한 HMG-CoA Reductase Inhibitor가 갱년기 한국여성의 골밀도에 미치는 영향
오한진,한기옥1,윤현구1,한인권1
성균관대학교 의과대학 삼성제일병원 가정의학과, 내과1
Abstract
Background
It has been found that new bone formation has been increased by HMG-CoA reductase inhibitors in vitro and in rodents. However, to date, results of epidemiologic analyses evaluating the link between use of these cholesterol-lowering drugs, bone mineral density and fracture have been mixed. Subjects and Methods: Two hundred postmenopausal Korean women, assessed by DEXA, participated in this study undertaken by Samsung Cheil Hospital in Seoul Korea. In this retrospective cohort study, the researchers measured biochemical markers of bone turnover and BMD of spine at baseline and again at 12-month. Differences of bone markers concentrations and spinal BMD between two groups were analyzed by independent sample t-test. Changes of markers and BMD from baseline in both groups were analyzed by paired sample t-test. Changes between both groups after 12-month treatment independent sample t-test were made. Statistical analyses were made by SPSS for windows version 10.0.
Results
At baseline, bone markers concentrations were similar in the two treatment groups of women. After 12-month treatment, these bone turnover markers concentration significantly decreased in both groups. The spinal BMD of both groups were increased significantly after treatment. But the differences of changes of BMD and bone markers concentrations between two groups were not changed significantly.
Conclusion
Our study does not support that statins in doses used for hypercholesterolemia increase bone formation. Randomized clinical trials are needed to confirm these findings.
Key Words: Postmenopausal women, HMG-CoA reductase inhibitor, BMD, Bone marker


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