Korean J Bone Metab > Volume 9(1); 2002 > Article
Korean Journal of Bone Metabolism 2002;9(1):45-52.
The Effects of Hormon Replacement Therapy and Pamidronate on the Bone Mineral Density and Serum Osteocalcin of Postmenopausal Women for 1 Year
갱년기 여성에서 호르몬 보충요법과 Pamidronate 1년간 병합치료가 골밀도 및 혈청 Osteocalcin에 미치는 영향에 관한 연구
김성한,김흥열,이천준,박은동,어완규*,최영식*,김기찬**,권영호***
고신대학교 의과대학 산부인과학교실, 내과학교실*, 재활의학과교실**, 정형외과학교실***
Abstract
Background
To evaluate the effects of hormon replacement therapy and pamidronate on the bone mineral density and serum osteocalcin in the postmenopausal women.
Methods
This prospective randomized clinical trial examined the effects of oral pamidronate and conjugated equine estrogen, in combination and seperately, on BMD and serum osteocalcin in 140 women. Treatment included pamidronate (group I, n=50), or conjugated equine estrogen (group II, n=50), conjugated equine estrogen plus pamidronate (group III, n=40) for 12 months. The bone density measurement was performed at months 6 and 12 months at the lumbar spine. Serum osteocalcin was also measured every six months.
Results
BMD of lumbar spine, it increased significantly during the treatment in Group I, Group II, and Group III (p<0.005). Serum osteocalcin in Group I, Group II and Group III decreased signifiantly at 12 months of treatment (p<0.005).
Conclusion
The combination treatment with pamidronate and conjugated equine estrogen is more effective in postmenopausal women with osteoporosis by decreasing the bone biochemical marker and by increasing the BMD.
Key Words: Pamidronate, Serum osteocalcin, BMD (Bone Mineral Density), Osteoporosis


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