| Higher Circulating hsCRP Evels are Associated with Lower Bone Mineral Density in
Healthy Premenopausal and Postmenopausal Women: Evidence for Link Between
Systemic Inflammation and Osteoporosis
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| 건강한 폐경 전후 여성에서 혈청 hsCRP 농도와
골밀도와의 상관관계
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| 배성진,손현영,변대근,나성수,고정민,김기수 |
| 울산대학교 의과대학 서울아산병원 내과학교실 |
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| Abstract |
Background
Factors involved in inflammation are linked with those critical for bone remodeling. We examined the association between serum high sensitivity C-reactive protein (hsCRP) levels and bone mineral density (BMD) in healthy women.
Methods
Serum concentrations of hsCRP and total alkaline phosphatase (ALP) were measured in premenopausal (n=3,662) and postmenopausal (n=1,031) women aged 30 years or older. BMD was measured at the femoral neck and lumbar spine using dual energy X-ray absorptiometry.
Results
Compared with normal subjects, log-transformed serum hsCRP levels were higher in premenopausal women who were osteoporotic and osteopenic at the femoral neck (p for trend=0.002) and lumber spine (p for trend=0.035) and higher in postmenopausal women who were osteoporotic and osteopenic at the femoral neck (p for trend=0.002), after adjustment for age, BMI and/or years since menopause. Serum total ALP level tended to be higher in the higher hsCRP quintiles in both premenopausal and postmenopausal women (p for trend<0.001). Multivariate-adjusted odds ratios for osteoporosis and osteopenia in the highest hsCRP quintile of premenopausal women were 1.38 (95% CI, 1.10 to 1.73) at the femoral neck and 1.35 (95% CI, 1.02 to 1.80) at the lumbar spine, whereas the odds ratio for osteoporosis in the highest hsCRP quintile of postmenopausal women was 3.26 (95% CI, 1.55 to 6.87) at the femoral neck.
Conclusion
These findings suggest that subclinical systemic inflammation may determine bone turnover rate and bone mass in healthy women.
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| Key Words:
C-reactive protein, Osteoporosis, Inflammation, Bone mineral density, Bone turnover |
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