Korean J Bone Metab > Volume 8(2); 2001 > Article
Korean Journal of Bone Metabolism 2001;8(2):173-180.
Paget s Disease of Bone - A Case Report -
두통을 주소로 내원한 52세 남자 환자에서 진단된 Paget 병 1례
김상완,박주경,정혜승,신찬수,박경수,김성연,조보연,이홍규,백선하*,강흥식**,김종재***
서울대학교 의과대학 내과학교실, 신경외과학교실*, 진단방사선과학교실**, 병리학교실***
Abstract
We report a 52 years old male patient with Paget s disease involving the skull, whole spine and pelvis. Paget s disease is a localized disorder of bone remodeling. Increased osteoclasts and their activity initiate the process at affected skeletal sites, and the increase in bone resorption is followed by increased new bone formation, altering bone architecture. The signs and symptoms of Paget s disease are varied, depending on the location of the involved sites and the degree of increased bone turnover. Patients with polyostotic Paget s disease have increased urinary excretion of hydroxyproline and elevated serum alkaline phosphatase. In this case, initial serum alkaline phosphatase and osteocalcin had been increased but both of them were much decreased after 2 month-treatment with alendronate 40 mg per day. Urine N-terminal telopeptide of type I collagen was not elevated before treatment but has increased after treatment.
Key Words: Paget s disease, Bone remodeling, Alkaline phosphatase


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