Korean J Bone Metab > Volume 9(2); 2002 > Article
Korean Journal of Bone Metabolism 2002;9(2):145-155.
Interaction Between Polymorphisms of Leptin Receptor and Estrogen Receptor Genes on Bone Mineral Density in Young Men
젊은 남성에서 렙틴 수용체 유전자형과 에스트로젠 수용체 유전자형의 상호작용과 골밀도의 상관관계
울산대학교 의과대학 서울아산병원 내과학교실, 핵의학과학교실1, 아산생명과학연구소2, 서울보훈병원내과3, 경북대학교 의과대학 정형외과학교실4
Previously, we observed that the Gln223Arg polymorphism of leptin receptor (LEPR) is associated with bone mineral density (BMD) in young men and that this association becomes more pronounced in overweight subjects. In addition, it has been reported that estrogenic actions might modify the effects of leptin system. We investigated interactions of estrogen and leptin systems on BMD in young men.
From 219 healthy volunteers aged 20~34 years, we genotyped the Gln223Arg variants of LEPR, and the PvuII and XbaI variants of ERα using the polymerase chain reaction-restriction fragment length polymorphism method. We determined serum concentrations of bioavailable estradiol (Bio-E2) and leptin, and BMD by dual energy X-ray absorptiometry.
Analysis of covariance revealed that both ERα genotypes significantly interacted with the Gln223Arg polymorphism of LEPR in relation to lumbar BMD (p=0.004 for the PvuII, and p=0.003 for the XbaI). The association between LEPR Gln223Arg polymorphism and lumbar BMD was more apparent in the subjects with the PP homozygotes of PvuII or in those with the X alleles of XbaI. However, the association was not significant in those with the Pp heterozygotes or pp homozygotes of PvuII and in those without the X alleles of XbaI. Interactions between serum Bio-E2 and leptin levels, between serum Bio-E2 levels and LEPR genotype, or between ERα genotypes and serum leptin levels, were not significant.
This study indicates that associations between the Gln223Arg polymorphism of LEPR and BMD are influenced by ERα gene polymorphisms in young men.
Key Words: Bone density, Men, Leptin receptor, Estrogen receptor, Polymorphism


Browse all articles >

Editorial Office
#1001, Hyundai Kirim Officetel, 42 Seocho-daero 78-gil, Seocho-gu, Seoul 06626, Korea
Tel: +82-2-3473-2231    Fax: +82-70-4156-2230    E-mail: editors.jbm@gmail.com                

Copyright © 2024 by The Korean Society for Bone and Mineral Research.

Developed in M2PI

Close layer
prev next