Korean J Bone Metab > Volume 10(2); 2003 > Article
Korean Journal of Bone Metabolism 2003;10(2):163-168.
Association between Bone Mineral Density and Interleukin-6 Gene Promoter Polymorphism in Healthy Young Korean Men
한국인 젊은 남성에서 골밀도와 IL-6 유전자 다형성과의 상관관계
김은숙,고정민1,김영일,홍정수2,김신윤3,김기수1
울산대학교 의과대학 울산대학병원 내과, 서울아산병원 내과1, 아산생명과학연구소2, 경북대학교 의과대학 정형외과3
Abstract
Background
The peak bone mass is recognized as an important determinant in the development of osteoporosis and genetic factors are the deciding determinants of peak bone mass. The cytokine interleukin-6 (IL-6) has important effects on osteoclast differentiation and function and it has been implicated in the pathogenesis of bone loss associated with estrogen deficiency. Recently, a G/C polymorphism in position -174 of the IL-6 gene promoter was found. We investigated associations between bone mineral density (BMD) and polymorphisms of the IL-6 gene in young men.
Methods
From 225 healthy volunteers aged 20~39 years, we identified the IL-6 genotypes (G/G, G/C, and C/C) using the polymerase chain reaction (PCR)-restriction fragment length polymorphism method. The PCR products were digested with NlaIII. BMD at the lumbar spine and femoral neck was measured using dual energy X-ray absorptiometry.
Results
& Conclusion: All subjects were G/G homozygous variants and no C allelic variants were found. The results suggest that the -174 G/C polymorphism of IL-6 gene may be absent or very rare in Korean men and IL-6 polymorphism is unlikely to be a important determinant of peak bone mass in Korean men.
Key Words: Interleukin-6 gene, Polymorphism, Bone density, Men


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