Korean J Bone Metab > Volume 13(2); 2006 > Article
Korean Journal of Bone Metabolism 2006;13(2):129-138.
Relationship between Bone Turnover Rate and A Systemic Inflammatory Marker in Korean Women
한국인 여성에서 골 전환율과 전신적 염증 표지자와의 상관 관계
울산대학교 의과대학 서울아산병원 내과학교실
In the previous study, we showed the relationship between elevated high sensitivity C-reactive protein (hsCRP) level and low bone mass in healthy women, and suggested subclinical inflammation may be a common pathway contributing to the joint occurrence of two diseases. But, association between serum hsCRP level and bone turnover rate, an independent risk factor for osteoporotic fracture like bone mineral density (BMD), has not been studied previously.
Serum hsCRP, bone specific alkaline phosphatase (BALP), and urinary N-terminal telopeptide of type I collagen (NTx) concentrations were measured in premenopausal (n=39) and postmenopausal (n=150) women aged 30 years or older. BMD was measured at the femoral neck and lumbar spine using dual energy X-ray absorptiometry.
Both serum BALP (γ=0.260, p<0.001) and urinary NTx (γ=0.288, p<0.001) were positively correlated with serum hsCRP levels even after adjustment for age, BMI, and years since menopause. When we categorized the subjects into four levels according to serum hsCRP concentration, both BALP and NTx were higher in the subjects with the highest hsCRP quartiles than those with the lowest quartile (p=0.007 and 0.001, respectively). Serum hsCRP levels showed a tendency to increase linearly in normal to osteoporotic subjects (P for trend = 0.044).
These findings propose that subclinical systemic inflammation may be the common linking factor between development of atherosclerosis and increased bone turnover rate in healthy women.
Key Words: Bone turnover rate, Bone density, C-reactive protein, Inflammation


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