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Korean Journal of Bone Metabolism 2006;13(1):33-39.
Relationships of Serum Leptin and Adiponectin Concentrations with Bone Mineral Density in Korean Postmenopausal Women
폐경기 여성에서 골밀도와 혈중 렙틴과 아디포넥틴 농도와의 관계
윤형근,복진현,이경욱,원종철,목지오,박형규,김여주,김철희,김상진,변동원,서교일,유명희
순천향대학교 의과대학 내과학교실
Abstract
Background
Overweight is associated with both higher fat mass and higher bone mineral density (BMD). Leptin is synthesized and secreted by adipocytes and serum concentrations are highly correlated with fat mass. It has been suggested that leptin levels may play a mediating role in maintaining bone mass. Unlike other adipokines such as leptin, adiponectin levels decreased in obesity. The purpose of this study was to investigate associations of serum leptin and adiponectin with BMD and bone turnover marker in postmenopausal Korean women.
Methods
We measured serum levels of leptin, adiponectin, bone-specific alkaline phosphatase (bone-ALP) and N-telopeptide of type I collagen (NTx) as well as lumbar spine and femoral neck BMD using dual energy X-ray absortiometry (DXA) in 33 Korean postmenopausal women. Result: Lumbar spine BMD was positively correlated with femoral neck BMD. Lumbar spine BMD was negatively correlated with bone turnover marker. Serum leptin level significantly increased in association with weight and body mass index (BMI) (r=0.69, p=0.0001 and r=0.78, p=0.0001 respectively), while serum adiponectin level didn't change. Serum leptin and adiponectin levels were not correlated with bone-ALP level, urine NTx, lumbar spine BMD or femoral neck BMD. Only femoral neck BMD decreased in association with serum adiponectin levels but it was not significant (r=-0.31, p=0.08).
Conclusion
Serum leptin and adiponectin concentrations did not appear to affect BMD directly in Korean postmenopausal women. Further research is needed to confirm the potential role of leptin and adiponectin to modulate the effects of adiposity on bone.
Key Words: Leptin, Adiponectin, Bone mineral density, Postmenopausal women


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