Lessons Learned from Long-Term Management of Hip Fracture in Patients with Osteopetrosis: A Report of Nine Hips in Five Patients

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J Bone Metab. 2019;26(3):201-206

Publication date (electronic) : 2019 August 31

doi : https://doi.org/10.11005/jbm.2019.26.3.201

Jae-Young Lim^1,*, Boo Seop Kim^2,*, Byung-Ho Yoon³, Jae Suk Chang⁴, Chan-Ho Park⁵, Kyung-Hoi Koo⁶

¹Department of Orthopaedic Surgery, Chung-Ang University College of Medicine, Seoul, Korea.

²Chung-Ang University H.C.S. Hyundae Hospital, Namyangju, Korea.

³Department of Orthopaedic Surgery, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea.

⁴Department of Orthopaedic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

⁵Department of Orthopaedic Surgery, Yeungnam University Medical Center, Daegu, Korea.

⁶Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Corresponding author: Byung-Ho Yoon. Department of Orthopaedic Surgery, Seoul Paik Hospital, Inje University College of Medicine, 9 Mareunnae-ro, Jung-gu, Seoul 04551, Korea. Tel: +82-2-2270-0028, Fax: +82-2-2270-0023, cragy0215@naver.com

*Jae-Young Lim and Boo Seop Kim contributed equally to this work and should be considered co-first authors.

Received 2019 August 13; Revised 2019 August 20; Accepted 2019 August 21.

Abstract

INTRODUCTION

Osteopetrosis is a rare hereditary bone disorder characterized by hard and brittle marble bone due to a defect in the function of osteoclasts.[1] This disease is generally divided into 3 types: (1) infantile malignant autosomal recessive; (2) intermediate autosomal osteopetrosis; and (3) benign autosomal dominant.[2] Increased bone density and frequent fractures are the clinical findings in the second group, and the third group which have normal life expectancy.[3]

The long bones are most frequently affected, fractures of the femoral neck and proximal (upper third) shaft being particularly common.[45] And these fractures are often result from minimal trauma even though the patients are very young.[67] Operative intervention needed in this area but physicians usually presents with unique technical challenges.[8910] Difficulties during their treatment encountered include iatrogenic fracture during implant placement, overheating and breakage of drills and saws, increased risk for osteomyelitis or nonunion.[11]

There are only few studies about hip fracture in patients with osteopetrosis, and most of these are case reports or descriptions of treatment in surgery on mixed fractures. To our knowledge, there has been no case series of hip fracture in adult patients with osteopetrosis, and we could not find any investigations aid in hip fracture management of these patients.

We therefore reviewed a group of patients with osteopetrosis who underwent hip fracture surgery from multi-center to assess (1) clinical presentation (fracture pattern and bilaterality); (2) prognosis (radiographic and clinical union rate, infection rate, refracture rate). This case series propose possible operative treatment in patients with osteopetrosis and highlights the potential peri-operative pitfalls in this rare surgical population.

METHODS

RESULTS

The median age of the patients at the first time of hip fracture was 36 years (range, 30–43 years) and all patients were followed for a minimum of 4.5 years (median, 8.1 years; range, 4.5–15 years). All patients had a previous fracture history other than hip and 4 patients involved bilateral sites.

Among 9 hips, transverse pattern fracture occurred at subtrochanteric area in 8 hips and femur neck in 1 hip. Surgery was performed in 7 hips, and extramedullary plates (dynamic hip screw or locking plate) were used due to difficulty creating medullary canal (Table 1). The bone union rate was 66% (6 in 9 hips); Seven of 9 hips were operated on and four of them were fused, and 2 hips were healed with conservative treatment but one was accompanied by malunion. The osteomyelitis occurred in 2 hips and 1 case of osteomyelitis of the proximal third of the femur had been treated with several repeated debridements and finally with femoral head resection (Fig. 1). One patient had been successfully treated with a dynamic hip screw for subtrochanteric fracture, but refracture occurred after complete union of at the tip of plate (Fig. 2).

Table 1

Operative details of patients

Fig. 1

(A) An anteroposterior view of the pelvis obtained at the time of injury shows a right transverse subtrochanteric fracture and osteosclerotic appearance of the osteopetrotic bone. The patient suffered a postoperative infection after surgery of left femoral neck fracture. (B) Radiographs at 4 years after injury shows a healed right subtrochanteric fracture with coxa vara. The chronic osteomyelitis of left hip finally treated with Girdlestone operation.

Fig. 2

(A) An anteroposterior view of the pelvis obtained at the time of injury shows a transverse subtrochanteric fracture in left hip. He had been treated with subtrochanteric fracture at the right hip (contralateral limb) 8 years ago. (B) Postoperative anteroposterior radiographs obtained 1.2 years after surgery shows refracture occurred at the tip of plate. (C) Refixation using long dynamic hip screw plate was performed and the radiograph showed complete union of the fractures at 12 months postoperatively.

DISCUSSION

Osteopetrosis is a disease which results into universal failure of the bone remodeling process and the fractures most commonly involve long bones such as femur.[213] Hip fracture surgery in patients with osteopetrosis is very challenging, because the bones are very hard with loss of medullary canal by insufficient resorption leading to excessive accumulation of bone matrix.[214] Although most of these fractures can be treated conservatively in child but operative fixation and urgent surgical treatment is crucial for adult patients.[15] However, if orthopaedic surgeons facing patients with these perplexing disease, even skilled physicians are reluctant to do surgery, because we don't know their prognosis and treatment results including the risk of infection or nonunion. To the best of our knowledge, this study has the largest number of treated hip fractures in patients with osteopetrosis, and we noticed that 6 of 9 hips (66%) reported being union at final follow up.

Several reasons may explain the predominance of high nonunion rate after surgery in these patients. Blood supply are deteriorated so non-union of periarticular fractures occur commonly in osteopetrosis.[1617] Surgery is technically difficult, because there is a high incidence of breakage of instruments and implants during the surgery due to the hardness of the bone.[10] In addition, it may not be possible to add supplementary autologous cancellous grafts in delayed or non-union because of absence of available cancellous bone.[18]

All cases of achieving bone union in the cohort showed bone union within a period compatible with general patients (range, 6–10 months after surgery). Recent studies have shown that adult type 1 osteopetrosis is not true osteopetrosis and his is due to the mutation of the LRP5 gene, which leads to an increase in bone mass, which is not known to be associated with osteoclast deficiency.[6192021] We believe that hip fractures in milder forms of osteopetrosis can be successfully treated with surgery similar to that of general patients.[1122]

Most of our patients sustained trivial trauma and had a transverse fracture configuration compatible with radiographic features of atypical femoral fractures.[23] De Palma et al.[14] reported the histology of fracture callus in a patient with autosomal dominant osteopetrosis, that they found microfractures were frequently noted, but remodeling did not occur. Osteopetrotic fractures do heal with unorganised woven bone but remodeling does not occur.[142124] In our case, peri-implant fracture occurred in one hip, stress concentration at the distal area of the plate may lead to a refracture (Fig. 2). Yoon and Park,[25] Chawla and Kwek [26] reported high incidence of peri-implant stress fractures (25%) and recommended the use of longer plates to span the whole bone would be recommended by passing through the most varus area of the femur which lead to preventing stress concentration.

Operative treatment of osteopetrotic fractures typically is reported as associated with many complications. Two (22%) of 9 hips in our cases develop osteomyelitis. Osteomyelitis is common in patients with osteopetrosis because of a reduced resistance to infection, attributed to the lack of marrow vascularity and impairment of white cell function. Bhargava et al.[27] recommended frequent change of drill bits and periodic cooling of the bone while drilling to prevent bone necrosis and infection. The most common complication of nonoperative treatment is coxa vara deformity and we also observed in 1 case among conservatively treated 2 hips. In one case, malunion was involved, but both conservatively treated hips had bone union, nonoperative treatment should be considered as an option.[26]

There were several limitations in our study. First, our study was retrospective and involved a small number of patients. This limitation was unavoidable as a result of the rarity of these patients. Second, we did not perform genetic testing so could not confirm the type of osteopetrosis. Third, many different treatment options were involved and the length of follow up was not uniform for all patients.

To help readers who faced with similar embarrassing problems, we presented our cases. Since clinical features of hip fracture in patients with osteopetrosis are similar to atypical femoral fractures, it might be helpful to apply the principles of surgical treatment of atypical femoral fractures. However, patients should be informed of the possibilities of several anticipated complications including intra-operative and post-operative course and risk of infection after surgery.

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