This study aims to identify a relationship between bone mineral density (BMD) of lumbar spine, and the weight and body mass index (BMI) in women.

The subjects were 1,143 females who visited the public health center. BMD (T-score), height and weight were measured and age, menopause, diabetes and hypertension, exercising status and smoking status were inquired by interview.

Among the subjects, 362 (31.7%) were in the normal group and 781 (68.3%) were in the abnormal group. As the result of the logistic regression analysis with BMI (Model I), the odds ratio of getting into the abnormal BMD group as age increases by 1 year marked 1.044 (95% CI = 1.009-1.080). The odds ratio of getting into the abnormal BMD group due to menopause was 2.663 (1.516-4.679) and the odds ratio according to lack of walking exercise was 2.597 (1.878-3.591). The odds ratio with 1 kg/m^{2} of BMI increase was 0.909 (0.862-0.959). In the logistic regression analysis with weight (Model II), the odds ratio of getting into the abnormal BMD group as age increases by 1 year marked 1.044 (1.009-1.080). The odds ratio of getting into the abnormal bone density group due to menopause was 2.575 (1.472-4.507) and the odds ratio according to lack of walking exercise was 2.598 (1.881-3.587). The odds ratio with 1 kg of weight increase was 0.963 (0.942-0.984). The Akaike's information criterion (AIC) values of Model I and Model II were 1196.18 and 1197.14 respectively, indicating Model I has the better compatibility of regression analysis model.

Weight, BMI and BMD had a positive correlation. However, the coefficient of correlation between weight and BMD was higher than the coefficient between BMI and BMD, which means low weight is much more likely to be related to osteoporosis with no other factor considered. On the other hand, under the condition considering age, height, menopause and walking exercise smoking status, low BMI is much more compatible as a risk factor for osteoporosis.

Osteoporosis is the most common disease among metalic bone diseases; it weakens bone mass by destructing the microstructures of bones thereby increasing the risk of fractures.[

Since osteoporosis gains more importance as elderly population increases, it becomes a social issue due to the financial burden as well as a main interest of modern medicine.[

The clinical importance of osteoporosis is a fracture occurrence and approximately more than a half of Caucasian women experience osteoporotic fractures in more than one body part if osteoporosis is not treated.[

National Osteoporosis Foundation in the US determined the main risk factors of osteoporotic fractures; of the risk factors, there are correctable factors and uncorrectable factors and the risk of fractures increases as the risk factors increase. A fracture history in the past, a family history of factures, smoking, and low body weight (≤ 57.8 kg) are known as the main factors determining the risk of femur fractures.[

Also, European Osteoporosis Foundation reported that the risk of fractures increased approximately 30% in the same age group in case of possessing more than 2 risk factors among the clinical risk factors and performing the bone mineral density (BMD) examination considering the risk factors was an excellent screening examination in a clinical perspective.[

The study was performed in subjects who visited a public health center in Seoul to have a BMD examination from May 2010 to March 2011 and the data was collected regarding as follows; BMI, body weight, height, and a BMD were measured and whether or not the subjects had hypertensions, diabetes, menopause, walking exercises, and smoking were examined by interviews. Since women with osteoporosis were the main interest of the study, men were excluded and the subjects who had female hormones in the past or currently, had steroids for a long time, had a thyroid disease or thyroid hormones, and had other osteoporosis treatments or currently took the medications for osteoporosis were excluded as well. Due to hysterectomy in the past, the cases where the exact age at the time of menopause was not able to be found were also excluded from the data.

T-score, a BMD, was used; when T-score was more than -1 and less than -1, it was defined as a normal BMD and an abnormal BMD, respectively, and these were used as dependent variables in the study. Age, height, body weight, BMI, duration of diabetes, duration of hypertensions, a menopausal status, duration after menopause, the age of menopause, a smoking status, and a walking exercise status were determined as independent variables that could influence on the normal and abnormal BMDs.

Smoking was defined based upon a current smoking status by interviews and a walking exercise was defined in cases of performing a walking exercise at least 30 minutes per day for five days a week.

In present study, T-score was measured utilizing dual energy X-ray absorptionmetry (DXA) and the average scores of the BMDs in anterior and posterior lumbar of lumbar L1-L4. Lunar DPX Bravo® from GE Inc., was used in a BMD measurement.

T-test and Chi-square test were carried out in order to examine the relationship between normal and abnormal T-scores and age, height, body weight, BMI, a hypertension status, a diabetes status, a walking exercise status, a smoking status, and a menopausal status. Logistic regression analysis was performed to analyze the relationship between normal and abnormal BMD groups and the independent variables including age, height, body weight, BMI, a hypertension status, a diabetes status, a walking exercise status, a smoking status, and a menopausal status. Statistical analysis was performed utilizing SAS 9.2 software (SAS Institute Inc., Cary, NC, USA).

Total 1,143 subjects were participated in the study; the average age was 62.0 ± 9.7, the average BMI was 23.8 ± 2.9 kg/m^{2}, 1,035 subjects were postmenopausal (90.6%), the average age at the time of menopause was 49.5 ± 4.7, 266 subjects were performed the walking exercises (23.2%), 128 subjects were smokers (11.2%), and 362 subjects were in the normal BMD group (31.7%) (

The average age of the normal BMD group and the abnormal BMD group was 56.7 and 64.5, respectively, and there was a statistically significant difference between them (

However, the average BMI of the normal BMD group and the abnormal BMD group was 23.9 kg/m^{2} and 23.7 kg/m^{2}, respectively, but there was no significant difference even though the BMI was higher in the normal BMD (

The subjects who had an abnormal BMD in the non-diabetes group and the diabetes group were 68.1% and 71.6%, respectively; this represented that the probability having an abnormal BMD was higher in the diabetes group but the difference was not statistically significant. The subjects who had an abnormal BMD in the non-hypertension group and the hypertension group were 65.7% and 74.6%, respectively; this indicated that the probability having an abnormal BMD was higher in the hypertension group and there was a statistically significant difference.

As the results of correlation, age, history of hypertension (HTNHx), period after menopause (PostMENO), smoking (SMK), exercise (EXE) were negative correlated, but Height, weight, BMI were positive correlated (

We investigated how an independent variable, which could be a risk factor in the normal and abnormal BMD groups including age, height, body weight, BMI, a menopausal status, a diabetes status, a hypertension status, a walking exercise status, and a smoking status, affects on the BMD. When multicollinearity was examined among several independent variables, variance inflation factor (VIF) between body weight and BMI was more than 100, indicating high VIF and VIF between the other variables was less than 10, indicating low VIF. Since BMI and body weight were the main variables in the relationship with a BMD, it was classified into Model I, focused on BMI, and Model II, focused on body weight, and then logistic regression analysis was performed including the other independent variables. The appropriateness of Model I and Model II was compared by Akaike's information criterion (AIC) values.

In Model I (BMI), the odd ratio of the relationship with the BMD depending upon age was 1.044 (95% CI = 1.009-1.080), indicating that the risk of an abnormal BMD increased by 5.6% as 1 year older when other variables were controlled. The odd ratio of the relationship with the BMD depending upon a walking exercise status was 2.597 (95% CI = 1.878-3.591), representing that the risk of an abnormal BMD increased by 2.6 times when the walking exercise was not performed. The odd ratio of the relationship with the BMD depending upon a menopause status was 2.663 (95% CI = 1.516-4.679) and this represented that the risk of an abnormal BMD increased by 2.7 times in case of the menopause group. The odd ratio of the relationship between BMI and a BMD, the main variables of interest, was 0.909 (95% CI = 0.862-0.959), indicating that the risk of an abnormal BMD decreased by 9% as BMI increased by 1 kg/m^{2} (

In Model II (body weight), the odd ratios of the relationship with the BMD depending upon age, a walking exercise status, and a menopause status were 1.044 (95% CI = 1.009-1.080), 2.598 (95% CI = 1.881-3.587), and 2.575 (95% CI = 1.472-4.507), respectively. The odd ratio of the relationship between BMI and a BMD, the main variables of interest, was 0.963 (95% CI = 0.942-0.984), indicating that the risk of an abnormal BMD decreased by 3.7% as body weight increased by 1 kg.

AIC values in Model I (BMI) and Model II (body weight) were 1,196.18 and 1,197.14, respectively, so the Model I had lower AIC value than that of Model II, indicating that Model I (BMI) was more appropriate than Model II (body weight). In other words, BMI would be more appropriate as the risk factor of an abnormal BMD when considering other variables such as age, height, smoking, walking exercise, menopause, diabetes, hypertension.

In the relationship between smoking, a walking exercise, and a menopause status and a BMD, the subjects with an abnormal BMD was 71.4% in the non-smoking group and 75.0% in the smoking group; the probability having the abnormal BMD was higher in the smoking group but the difference was not statistically significant with

As a result of Chi-square test analysis when other variables were not controlled, higher proportion of the subjects who had an abnormal BMD was observed in the non-diabetes group compared to the diabetes group however the difference was not statistically significant. In contrast, the hypertension group had higher proportion of the subjects with an abnormal BMD compared to the non-hypertension group and there was a statistically significant difference.

On the other hand, there was no statistically significant difference in the relationship between hypertensions and diabetes and a BMD in the result of logistic regression analysis as the other variables were controlled. Hypertension is associated with low BMD but there are no studies suggesting that it is the risk factor of osteoporosis. The average BMI in the normal BMD group and the abnormal BMD group was 23.9 kg/m^{2} and 23.7 kg/m^{2}, respectively; it was lower in the abnormal BMD group but t-test analysis showed that there was no significant difference (

Height, body weight, and BMI were all positively correlated with dependent variable T-score and each independent variable; height and body weight exhibited the stronger correlation with T-score compared to BMI. In the study analyzed the data of Women's Health Initiative (WHI), Cardiovascular Health Study (CHS), and Epidémiologie de l'Ostéoporose (EPIDOS),[

Given the results above, body weight represented a higher association with BMD compared to BMI and the association between BMD and BMI was more appropriate than that with body weight if other variables including age, height, menopause status, diabetes, hypertension, walking exercise, smoking were taken account.

In conclusion, body weight exhibited a stronger association with a BMD without the considerations of other variables, while BMI was more appropriate to explain the association with a BMD when considering variables such as age, a menopause status, exercise, a current smoking status. Further, as BMI better reflect the obesity degree than the simple body weight, it will be useful, as a risk factor of osteoporosis to explain the relationship between the obesity and the BMD.

There are various risk factors of osteoporosis and risks of fractures due to osteoporosis would be increased when such multiple risk factors are applied altogether rather than single factor; thus, effects of such factors including non-physical activities (or no exercise), smoking, menopause are critical.

In the study, we would like to investigate the particular effects of exercise on osteoporosis. The limitations of the study are that exercises can be subdivided into either aerobic and body weight load exercise or low, medium and high intensity exercise depending upon the types and the intensity of exercises, respectively; further, it would be different effects from exercise depending on the duration of the exercise (e.g., 0.5, 1, 1.5, and 2 hr etc.). Thus, it is necessary to quantify the exercise utilizing the scoring system that is classified with criteria including types, intensity, and duration of exercise and then investigate the association with a BMD. On the other hand, other factors that may affect a BMD (e.g., calcium and caffeine intake) should be considered and further studies are needed regarding these factors.

General characteristics of study subjects

BMI, body mass index

Comparisons between normal and abnormal bone density

BMI, body mass index

Correlation between T-score and other variables

^{*}^{**}^{***}

BMI, body mass index; DMHx, histroy of diabetes; HTNHx, history of hypertension; PostMENO, period after menopause; SMK, smoking; EXE, exercise

The results of logistic regression for normal and abnormal bone density

( ), 95% confidence interval

BMI, body mass index; AIC, Akaike's information criterion