| A Case of Paget s Disease Treated with Pamidronate |
| 파미드로네이트로 치료한 파제트병 (Paget s Disease) 1례 |
| 이창욱,강자영,최현아,한승석,김해성,김성훈,정호연,한기옥,박원근,윤현구,한인권 |
| 성균관대학교 의과대학 삼성제일병원 내과 |
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| Abstract |
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Paget s disease is a chronic disorder of excessive and abnormal bone remodeling in which there is an uncoupling of osteoclastic bone resorption and osteoblastic new bone formation. The excessive remodeling gives rise to bones that are extensively vascularized, weak, enlarged, and deformed with subsequent complications. Paget's disease can affect one or more bones in the body, and the most frequently affected bones are the pelvis, the bones in the skull, the long bones, and the collar bones. The prevalence of Paget's disease increases with age, and there is geographic diversity in prevalence across the nations. While the prevalence in the United States and England are reported to be just below 1%, it is extremely rare in Korea. Although there remains considerable controversy regarding its etiology, several different methods of management have now become available.
We report a case of Paget's disease in 51 year-old woman who was treated with pamidronate and showed improvement in the symptoms and the serum alkaline phosphatase level.
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| Key Words:
Alkaline phosphatase, Paget s disease, Pamidronate |
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